Government Study Of BPA Backs Its Safety, But Doesn't Settle Debate

10 hours ago
Originally published on September 13, 2018 8:31 pm

Government scientists have presented new evidence that the plastic additive BPA isn't a health threat.

Low doses of the chemical given to hundreds of rats, "did not elicit clear, biologically plausible adverse effects," said K. Barry Delclos, a research pharmacologist at the Food and Drug Administration's National Center for Toxicological Research.

Delclos made the remarks Thursday during an online presentation in which he summarized an important part of a $30 million project called CLARITY-BPA, which was launched in 2012 to resolve questions about the chemical's safety.

The results of the rat study had previously appeared in a draft report on BPA (also known as bisphenol-A) released in February. But since then, the research has undergone peer review and revisions, Delclos said.

During his online presentation, Delclos provided an overview of the two-year study, which involved thousands of rats given a wide range of BPA doses.

Rats that got at least a thousand times more BPA than consumers are exposed to showed effects similar to those produced by the hormone estrogen. These included changes to the reproductive system and a greater risk of reproductive tumors.

But at doses meant to replicate human exposure, there was no pattern indicating any health or behavior problems, Delclos said.

He declined to comment directly on BPA's safety or the FDA's position that the chemical is safe to use in most plastic food containers. But Delclos noted that government agencies around the world have now weighed in on BPA, and that "most of these regulatory agencies currently conclude that BPA does not pose a risk at estimated dietary exposure levels."

BPA has been used for decades in products like water bottles, and in the lining of some food cans. And studies show that tiny amounts can get into our bodies.

Scientists agree that BPA can act like estrogen. But early government studies found no evidence that people are exposed to enough BPA to produce an effect.

Meanwhile, studies by some academic scientists suggested that even low levels of BPA can cause everything from obesity to breast and prostate cancer, to diabetes, to behavioral problems.

CLARITY-BPA was supposed to resolve the conflict. But it hasn't.

Academic scientists whose research has suggested that even tiny amounts of BPA affect lab animals have raised questions about the government's rat study since the February draft became available. And the day before Delclos' presentation, they held an online press conference to pre-emptively challenge the results he was expected to describe.

During that press conference, Laura Vandenberg, an associate professor at the University of Massachusetts at Amherst, said her own analysis of the study data comes up with a different result — low doses of BPA are a problem.

"There were significant effects of BPA in both males and females," she said, citing groups of rats that had unusually high rates of breast cancer and prostate inflammation.

That sort of risk will be shown more clearly when the second part of CLARITY-BPA is finalized next year, Vandenberg said. That part will feature studies from more than a dozen academic scientists who received CLARITY funding, including some who found that very low doses of BPA did cause health problems even when higher doses did not.

But some academic scientists who participated in CLARITY have only praise for the project, and its results so far.

A study by Norbert Kaminsky of Michigan State University found that low doses of BPA had no effect on a rat's immune system.

"We probably measured about 125 endpoints in more than 700 animals," Kaminsky says. "This study was extremely comprehensive, and I am very confident and comfortable in the results."

The debate about BPA is likely to intensify as CLARITY scientists work to assemble their final report next year, says Patricia Hunt, a professor at Washington State University who has studied BPA for decades but is not part of CLARITY.

Many academic scientists who specialize in chemicals like BPA think the government's effort is badly flawed, she says, adding that they disagree with the type of rat the government chose and fear that the presence of BPA is some animals who were supposed to be BPA-free undercuts the study's validity.

"What we're going to see over the course of the next few of weeks is a lot of fighting because there's a lot of anger on both sides," Hunt says.

And all that fighting be misguided, she says, because the plastics industry has already removed BPA from many products.

Instead, she says, they have begun using a range of chemicals that are very similar to BPA, but haven't been studied as carefully.

On Thursday, Hunt published a paper suggesting that one of these substitute chemicals, called BPS, caused the same effects in lab animals she'd seen with BPA.

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Firefighters and police officers in Massachusetts are rushing to the towns of Lawrence and Andover tonight. Dozens of houses have exploded into flames apparently connected to a problem with the gas. Lawrence General Hospital says it is treating fire victims, and people are being told to evacuate, which has led to gridlock and traffic jams.

Maggie Penman of member station WGBH joins us from Andover. And, Maggie, the images that I'm seeing on TV are hard to fathom. What are you seeing where you are?

MAGGIE PENMAN, BYLINE: Hi, Ari. So where I am in Andover's town center, it's actually pretty eerie. All the lights have gone out because the electricity to this whole area has been cut. So it's kind of like a ghost town. All the windows are dark. All the businesses are closed. And there have been a lot of people trying to get out of town, a lot of people wandering around because they've been told to leave their homes, and they're not quite sure where to go right now.

SHAPIRO: Everybody in the country had been watching a pending natural disaster with the hurricane, and this came seemingly out of nowhere. Do you have any sense of what the scale of this is?

PENMAN: So at its peak, I have heard that there were as many as a hundred fires burning, but no one is quite sure what the cause was. It seems to have been a problem with the local gas provider. And basically anyone who has gas service in their home in these communities has been told to leave their home. So I've seen a lot of people standing at the edge of their driveway, lots of traffic of people trying to evacuate and, you know, get out of here basically.

SHAPIRO: The number of people being told to evacuate their homes on such short notice without plans for where they're going to go has got to be causing just chaos.

PENMAN: Yeah it's - it was total chaos on the highway, and there were several exits that were closed, which only added to the traffic and the chaos because basically the emergency response teams were trying to prevent people from coming into these communities and also simultaneously get people out of them. So it was total chaos, tons of traffic, basically gridlock on 495, where three exits in a row were closed for these communities.

SHAPIRO: As we mentioned, at least one hospital has said that it's already treating fire victims. Do you have any sense of how many people might have been injured or killed in these explosions and fires?

PENMAN: I don't know how many people have been injured. I know here in Andover, there was a firefighter who was injured, and several people have been injured as well. But I'm not sure of exact numbers. I know that all of the area hospitals have been ready and prepared to receive people.

SHAPIRO: Have you talked to people in the area? There must be an incredible sense of fear and uncertainty tonight.

PENMAN: It's interesting 'cause there is a lot of fear and uncertainty, but there's also a lot of people who are sort of in this situation of being told to hurry up and wait. There are a lot of people walking around who don't know where to go. As I said, all the businesses are closed. All the lights are out - so, you know, not being able to go into your home but also not necessarily having anywhere else to go either.

SHAPIRO: Maggie Penman of member station WGBH, thanks for talking with us tonight.

PENMAN: Thanks so much, Ari.

SHAPIRO: Maggie Penman is covering that unfolding story of dozens of houses bursting into flames, a mass evacuation in these towns north of Boston. And we will have more on the story as it unfolds. Transcript provided by NPR, Copyright NPR.