David Koch is stepping down from the Koch brothers' network of business and political activities, including Wichita-based Koch Industries.
David Koch, 78, is suffering from deteriorating health, according to a letter that older brother Charles Koch sent to company officials Tuesday.
Charles Koch wrote: "We are deeply saddened by this, as we miss David's insightful questions and his many contributions to Koch Industries.
"David has always been a fighter and is dealing with this challenge in the same way."
Charles Koch said his brother's "guidance and loyalty, especially in our most troubled times, has been unwavering."
"David has never wanted anything for himself that he hasn't earned, as his sole desire has always been to contribute," he wrote.
David Koch is leaving his roles as executive vice president and board member for Koch Industries and a subsidiary, Koch Chemical Technology group, where he served as chairman and chief executive officer.
Koch, who lives in New York, is also stepping down as chairman of the board for the Americans For Prosperity Foundation, the charity related to Koch brothers' primary political organization.
Charles Koch, 82, had assumed a more visible leadership role in the brothers' affairs in recent years. He will continue to serve as the CEO of Koch Industries and the unofficial face of the network's political efforts.
Using money from the family business empire, the Koch brothers have created what is likely the nation's most powerful political organization with short- and long-term goals. Their network has promised to spend $400 million to shape the 2018 midterm elections.
They have also devoted significant time and resources to strengthening conservative influence on college campuses, in the Hispanic community and in the nonprofit sector.
Democrats have demonized the Koch brothers for their outsized influence in conservative politics over the last decade. Former Senate Majority Leader Harry Reid regularly attacked Republicans for what he called a "Koch addiction."
Yet the Kochs have clashed with the Trump administration at times.
Citing concerns about Trump's style and substance, the network refused to endorse either presidential candidate in the 2016 election. And while they have praised Trump's policies on taxes, deregulation and health care, they have aggressively attacked the Republican administration's trade policies.
On Monday, the Koch network announced a multi-million-dollar campaign to oppose Trump's tariffs and highlight the benefit of free trade.
David Koch, who served as the Libertarian Party's vice presidential candidate in 1980, had begun to focus more on philanthropy in recent years. The Manhattan resident donated $150 million to New York City's Memorial Sloan Kettering Cancer Center in 2015, the largest gift in the organization's history.
He has also given $185 million in donations to the Massachusetts Institute of Technology, his alma mater.